Description
‘Hot Topics in Cell Biology’ is a definitive overview of the ‘state of the art’ in cell biology. It is based on papers presented by leading researchers at the Spanish Society for Cell Biology’s XIV Congress – a Congress that strives to achieve scientific excellence. Each participant was asked to prepare a ‘mini review’ of current and likely future development in their area of research. This book is based on those reviews. As such, it is therefore an analysis of current and future trends.
Key features include: contains contributions from some of the world’s leading researchers; the book is multidisciplinary, covering almost all topics in cell biology: from basic to applied cell biology, and a wide variety of models: from in vitro to vivo models, ranging from fish to rodents and humans; each ‘mini review’ is an easy-read piece, describing the state of the art on a topic with clear language and in a summary format; the mini review format makes the book attractive not only to readers involved in cell biology research and teaching, but also professionals from other disciplines and students; and the book takes a truly multidisciplinary approach; it covers a wide array of topics, and the book reflects how cell biology interacts with other disciplines.
Readership: Cell biology academics and researchers
Contents: Introduction, Dynamics of cell compartments, The intracellular trafficking, Cell signaling, Autophagy, apoptosis and cell homeostasis, Cell biology of aging, Plant cell biology, Methods in cell biology, Applied cell biology, Cell biology of cancer’ Cell therapies and tissue engineering, Neurodegeneration and cell biology, and Nanotechnology and cell biology: challenges and opportunities
Author Biography: Dr Jose Becerra is Professor of Cell Biology at the University of Málaga (Spain) since 1989. He has been Dean Secretary, Vice-Dean and Dean of the Faculty of Sciences of Málaga, and is now the Head of the Department of Cell Biology, Genetics and Physiology. From 2001 to 2003 he was the Director of the Andalusian Laboratory of Biology (LAB, Seville), which was converted in the Andalusian Centre for Developmental Biology (CABD) under his term. He is a member of the Technical Committee of the National Stem Cell Bank since 2007, patron of the Board of Trustees of IMABIS Foundation (Mediterranean Institute for the Advance of Biotechnology and Health Research), coordinator of the Biomaterials and Tissue Engineering Area of the the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and member of the Direction Committee of the CIBER-BBN. His research is focused on bone and cartilage regeneration, which his group studies in different model organisms, ranging from zebrafish to humans. His laboratory is developing therapeutic tools based on mesenchymal stem cells, recombinant proteins with specific molecular domains (bFGF, BMP-2 and BMP-6), peptides and biomimetic biomaterials. He has authored over one hundred articles and seven patents.
Dr Leonor Santos-Ruiz is Senior Researcher of the CIBER-BBN network at the Andalusian Center for Nanomedicine and Biotechnology (BIONAND). She started her career studying the cellular and molecular basis of lower vertebrates’ amazing ability for tissue regeneration, with a special attention to bone and spinal cord repair. She moved on to apply her knowledge in regenerative biology to therapeutic bone repair through two main research approaches: study the interactions cell-materials in order to engineer bone tissue; and study the molecular basis of the differentiation pathway stem to progenitor cell and then on to osteoblast and osteocyte. This latter approach drove her to the study of skeletal dysplasia, a field in which she is trying to develop combined cell and tissue engineering therapies. She has worked in University of Málaga (Spain); Istituto Nazionale per la Ricerca sul Cancro (INRC-CBA; Italy), and Institute of Child Health (ICH-UCL; UK).
章節
- Cover
- Half Title
- Title
- Copyrights
- List of Contents
- Foreword
- Contributors
- 1. INTRODUCTION
- An overview of cell biology in the 21st century.
- 1.1. Dynamic of cell compartments
- Dynamics of cell compartments and pathological implications.
- Non-Muscle Myosin II Integrates Cell Adhesion and Migration by Controlling the Compartmentalization of Adhesive Signaling.
- A 3D-functional-screening identifies new components of the machinery for epithelial lumen morphogenesis.
- 1.2. The intracellular trafficking
- Some basic ideas about the intracellular membrane trafficking.
- Introducing the temporal dimension to the ultrastructural analysis of membrane budding in S. cerevisiae.
- 1.3. Cell signalling
- Cell signalling and communication.
- MYADM, a member of the MAL protein family, regulates Rac1 targeting to membrane rafts and cell migration.
- 1.4. Autophagy, apoptosis and cell homeostasis
- An overview of cell homeostasis.
- Differential regulation of autophagy, proliferation and cell survival during otic neurogenesis.
- 1.5. Cell biology of aging
- Overview of cell senescence and longevity.
- Mitochondrial homeostasis and healthy aging.
- 1.6. Plant cell biology
- Cell biology of plant development and adaptation.
- Root Behaviour: From Sensory Perceptions to Motoric Actions.
- Plant steroid hormones control cell cycle and differentiation in the Arabidopsis root.
- Nuclear reprogramming of plant differentiating cells: remodelling of nuclear domains and epigenetic regulation.
- Multi-gene engineering for reconstruction and extension of complex plant biosynthetic pathways and sociopolitical constraints limiting the transition from the laboratory to the market place.
- 1.7. Methods in Cell biology
- The last advances in TEM for the in situ molecular recognition.
- Image analysis as a service for cell-based assays and tissue cultures.
- In Vivo non-Invasive Bioluminescence Imaging: a Short Course.
- 2. APPLIED CELL BIOLOGY
- Cell biology and beyond: Applications of cell biology.
- 2.1. Cell biology of cancer
- Cancer cell biology: key points in future treatments of cancer.
- Ribosome biogenesis, cell cycle progression and tumorigenesis: Key points in ribosomopathies and future treatment of cancer.
- Epithelial plasticity and metastasis: New regulatory mechanisms.
- 2.2. Cell Therapy and Tissue Engineering
- Regenerative Medicine in the Context of Cell Biology: Technical and Practical Approaches.
- The Stem Cell And Its Neighborhood: The Niche Of Stem Cells In Animal And Plant Organisms.
- Efficiency and Biosafety in Cell Therapy.
- New strategies for cardiac regeneration.
- Stem cells in Skin Tisular Engineering.
- Modeling Parkinson’s disease using induced pluripotent stem cells.
- 2.3. Neurodegeneration and Cell Biology
- Neurodegeneration: A challenge for cell biology in the 21st century.
- Neuron Biology In Health And Disease.
- Brain derived neurotrophic factor: Neuronal dysfunction versus cell death in Huntington’s Disease.
- Oligomeric Amyloid-Beta And Neuronal Dysfunction In Alzheimer’s Disease.
- Stem Cells And Adult Neurogenesis In The Human Brain.
- 2.4. Nanotechnology and Cell Biology: challenges and opportunities
- Functional Magnetic Nanoparticles For Life Sciences.
- Tumor targeting of drug-loaded magnetic nanoparticles by an external magnetic field for in vivo cytokine delivery in cancer immunotherapy.
- Rational design and development of nanotechnology-based vasoactive intestinal peptide (VIP) applications in health research.
- 3. COROLLARY
- Towards a Cell Evo-Devo.